Jane McGlade, PhD
Research Institute
Associate Chief of Research, Faculty Development
Research Institute
Director
SIDNET
Principal Investigator
The Arthur and Sonia Labatt Brain Tumour Research Centre
Senior Scientist
Cell Biology
University of Toronto
Professor
Medical Biophysics
Fax: 416-813-8456
e-mail: jmcglade@sickkids.ca
Research Interests
- Signal transduction
- Cancer
- Protein biochemistry
- Development
Research activities
My research is directed towards understanding the regulation of signal transduction pathways, that control normal embryonic development and cellular function, and which are relevant to disease states such as cancer. Recently we have focused specifically on a family of intracellular adapter molecules that function to integrate, localize, and down regulate signal transduction cascades. My lab has identified new adapters such as GADS and MARS that function in antigen receptor signalling, and NUMB and LNX which regulate the activity of transmembrane receptors that determine cell fate during development.
Future research interests
Currently work in my laboratory focuses on the functional characterization of these molecules, as well as the on going discovery of new regulators of signal transduction pathways. In addition the lab studies the role of adaptors in directing protein ubiquitylation and vesicle trafficking.
Publications
Intellectual Property
Adapter Gene, Corporate Ventures